Detailed Abstract
[Liver Oral Presentation 3 - Liver Disease/Surgery]
[LV OP 3-3] Comparison of the prognosis of hepatic resection with initial treatment and hepatic resection after transarterial chemoembolization
Ho Joong CHOI, Dong Goo KIM, Yumi KIM, Bong Jun KWAK, Jae Hyun HAN, Tae Ho HONG, Young Kyoung YOU
Surgery, Seoul St. Mary’s Hospital, The Catholic University of Korea, Korea , Korea
Introduction : The treatment modality of hepatocellular carcinoma (HCC) varies, so several staging systems have been developed to guide management of HCC. This study was performed to review the outcomes of HCC after hepatic resection with or without transarterial chemoembolization (TACE).
Methods : From January 2005 to December 2015, 274 patients who underwent hepatic resection with or without TACE for HCC in our center were included. And then, they were divided into resection only (Resection) group and resection after TACE (RAT) group. To assess the outcomes associated with TACE, we evaluated recurrence, the disease-free survival rate (DFS), the overall survival rate (OS), and various other factors based on the characteristics of patients and tumors
Results : Of the 274 patients, 5-year DFS and OS rates were 42.6% and 69.8%. Resection group was 208 (75.9%) patients and RAT group was 66 (24.1%) patients. We found no statistically significant difference in the DFS and OS rates between Resection and RAT group. However, when RAT group was divided into responder (complete response and partial response) and non-responder (stable disease and progressive disease) according to modified response evaluation criteria in solid tumors (mRECIST), Resection group and responder group showed no difference between DFS and OS, but non-responder group showed significantly worse in both DFS and OS.
Conclusions : This study showed that immediate hepatic resection has similar prognosis as resection after TACE. If resection is possible, there is no need to plan TACE. And if TACE is performed, non-responders to TACE need to be cautious in considering resection later.
Methods : From January 2005 to December 2015, 274 patients who underwent hepatic resection with or without TACE for HCC in our center were included. And then, they were divided into resection only (Resection) group and resection after TACE (RAT) group. To assess the outcomes associated with TACE, we evaluated recurrence, the disease-free survival rate (DFS), the overall survival rate (OS), and various other factors based on the characteristics of patients and tumors
Results : Of the 274 patients, 5-year DFS and OS rates were 42.6% and 69.8%. Resection group was 208 (75.9%) patients and RAT group was 66 (24.1%) patients. We found no statistically significant difference in the DFS and OS rates between Resection and RAT group. However, when RAT group was divided into responder (complete response and partial response) and non-responder (stable disease and progressive disease) according to modified response evaluation criteria in solid tumors (mRECIST), Resection group and responder group showed no difference between DFS and OS, but non-responder group showed significantly worse in both DFS and OS.
Conclusions : This study showed that immediate hepatic resection has similar prognosis as resection after TACE. If resection is possible, there is no need to plan TACE. And if TACE is performed, non-responders to TACE need to be cautious in considering resection later.
SESSION
Liver Oral Presentation 3
Room C 3/30/2018 4:10 PM - 5:00 PM