The horizons for Hepato-Biliary Surgery and Living-Donor Liver Transplantation (LDLT) are ever-changing in ways amply reflected in this presentation. The 1990s was surely remembered as the decade during which Korean H-B Surgery and LDLT became fully established by the Asan Medical Center, University of Ulsan College of Medicine; Choledoscopic Intrahepatic Stone Removal by Electrohydrolic Shock Wave Lithotripsy in 1989, Laparoscopic Cholecystectomy in 1990, pre-operative PVE (portal vein embolization) for safe major hepatectomy of Hilar CA in 1991, Combined Liver Resection and Vascular Reconstruction for Hilar CA in 1993, pre-op PVE for major hepatectomy in cirrhotic liver with Hepatocellular CA in 1993, Hepato-Pancreato-Duodenectomy for diffuse type Hilar CA in 1993, Pediatric LDLT in 1994, Veno-Venous Bypass(Bio-pump & Anthrone passive tube) in Surgery of H-B-P cancers involving Portal Vein in 1994 and 1995, Adult LDLT in 1997, and Hypothermic Perfusion Hepatectomy (Ex-vivo resection and autotransplantation) in 1999. Improved survival results have generated widespread confidence in the procedures. In 2000, our institute became one of the world leading center for treating hilar CA by resection number and outcomes. In LDLT, our surgical innovations have overcome many of the formidable obstacles; Modified right-lobe graft to relieve anterior sector congestion and Dual grafts have expanded our adult LDLT Program with ensuring donor safety and adequate graft-size. IOP (intraoperative portography) with PV stenting for near complete obstruction of PV associated with portal flow steal, and Extra-anatomic bypass portal reconstruction for pv obliteration have changed the selection criteria of recipients in view of technical aspects ranging from impossible to possible. Aggressive pre-transplant down-staging of tumor, major cirrhotic liver resection with pre-resection TACE and PVE, and No-touch en-bloc hepatectomy for HCC to mimize the risks of recurrent HCC have become our practice with the excellent long-term survival. Success begets enthusiasm and more success. Our institutional challenge has primarily participated in the re-invention of Hepato-Biliary Surgery and LDLT in nation-wide and world-wide.