Introduction : Despite the improvement of special treatment methods, the 5-year survival rate according to different authors is 1-10%. In 2016 in Kazakhstan, the number of people who fell ill at the PCa was 1028, while the one-year mortality rate was 65,1%. Radiation therapy (RT) is one of the treatment options for malignant neoplasm of the pancreas. Our purpose is to improve the treatment results of patients with PCa.

Methods : The method of IMRT was applied in 8 patients with adenocarcinoma of the third stage. 5 of them (62.5%) are primary patients without any treatment, 3 (37.5%) - after not radical operations. At the end of the course of treatment with a patient with PCa, the quality of life did not worsen. There are no early radiation reactions of high toxicity (RTOG 3-4). The evaluation of the quality of the conducted RT was carried out by Multispiral Computed Tomography (MSCT) with contrast enhancement (bolus + per. os).

Results : The best results are observed in a patient whose tumor size decreased from 6.1x5.1x3.8 cm to 4.1x3.8x3.7 cm in 1 month after radiation therapy. As a result, in 5 primary patients after 2,0 Gy per fraction to 55-60 Gy observed partial regression of the lesion, 3 patients underwent postoperative radiation therapy for prevention of disease recurrence (they are follow-up).

Conclusions : The application of the technique of intensively modulated radiotherapy in patients with malignant neoplasm of the pancreas, increases access to new methods of treatment, and improves the quality of life and the survival rate.