Detailed Abstract
[Poster - Pancreas Disease/Surgery]
[P104] Risk factors associated with early recurrence of br-pc after nacrt
Nobuhiro TSUCHIYA1,2, Ryusei MATSUYAMA1, Takashi MURAKAMI1, Yasuhiro YABUSHITA1, Yu SAWADA1, Ryutaro MORI1, Takafumi KUMAMOTO1, Tetsuya NAKATSURA2, Itaru ENDO1
1Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Japan
2Division of Cancer Immunotherapy, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Japan, Japan
Introduction : Early recurrence is common after curative surgery for pancreatic cancer and is associated with poor prognosis. This study aimed to identify risk factors of early recurrence after curative pancreatectomy in borderline resectable pancreatic cancer (BR-PC) after neoadjuvant chemoradiation therapy (NACRT).
Methods : This study included 61 BR-PC patients who underwent curative resection after NACRT between July 2009 and June 2014. Patients were divided into the early recurrence group, who developed recurrence within 12 months after pancreatectomy (n = 30), and the non-early recurrence group (n = 31). Patient characteristics, clinicopathological factors of early recurrence and survival time were retrospectively compared between the groups.
Results : Univariate analysis showed SUVmax (p = 0.039), microvascular invasion (p = 0.003), lymph node metastasis (p = 0.015), to be associated with early recurrence. Receiver operating characteristics (ROC) curves for recurrence-free survival (RFS) identified SUVmax of 4.1 as optimal cut-off. By multivariate analysis, there were significant differences in SUVmax > 4.1 (p = 0.017) and microvascular invasion (p = 0.002) between the groups. SUVmax > 4.1 was associated with poorer RFS compared with patients with SUVmax ≤ 4.1 (8.1 vs 41.0 months, p = 0.004).
Conclusions : The present results indicate that SUVmax >4.1 is an independent predictor of poor RFS after NACRT of BR-PC. Although R0 resection for BR-PC after NACRT was performed, about half of the patients had recurrence within one year. Hence, more powerful and effective chemotherapy is needed to reduce distant metastasis.
Methods : This study included 61 BR-PC patients who underwent curative resection after NACRT between July 2009 and June 2014. Patients were divided into the early recurrence group, who developed recurrence within 12 months after pancreatectomy (n = 30), and the non-early recurrence group (n = 31). Patient characteristics, clinicopathological factors of early recurrence and survival time were retrospectively compared between the groups.
Results : Univariate analysis showed SUVmax (p = 0.039), microvascular invasion (p = 0.003), lymph node metastasis (p = 0.015), to be associated with early recurrence. Receiver operating characteristics (ROC) curves for recurrence-free survival (RFS) identified SUVmax of 4.1 as optimal cut-off. By multivariate analysis, there were significant differences in SUVmax > 4.1 (p = 0.017) and microvascular invasion (p = 0.002) between the groups. SUVmax > 4.1 was associated with poorer RFS compared with patients with SUVmax ≤ 4.1 (8.1 vs 41.0 months, p = 0.004).
Conclusions : The present results indicate that SUVmax >4.1 is an independent predictor of poor RFS after NACRT of BR-PC. Although R0 resection for BR-PC after NACRT was performed, about half of the patients had recurrence within one year. Hence, more powerful and effective chemotherapy is needed to reduce distant metastasis.
SESSION
Poster
Poster / Exhibition Hall and Lobby(2F) 1/1/1970 9:00 AM - 9:00 AM