Detailed Abstract
[Poster - Pancreas Disease/Surgery]
[P103] The value of infectious biomarkers for prediction of complication after pancreatic surgery
Yuan FANG1, Gang JIN2, Xubao LIU3, Yajin CHEN4, Bei SUN5, Zhongtao ZHANG6, Wenchuan WU1, Wenhui LOU1
1Pancreatic surgery, Zhongshan Hospital, Fudan University, China
2Pancreatic surgery, Changhai Hospital, Second military medical University, China
3Pancreatic surgery, West China Hospital, Sichuan University, China
4Pancreatic surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, China
5Pancreatic surgery, First Affiliated Hospital, Harbin Medical University, China
6Pancreatic surgery, Beijing Friendship Hospital, China, China
Introduction : To assess the predictive value of biomarkers for early complication after pancreatic surgery.
Methods : 950 cases were recruited from 6 centers in China. Procalcitonin,C-reactive protein and WBC were measured on 1st, 3rd and 5th postoperative day . Chi-square test was for the complication risk factors. One-way ANOVA was for the comparison between the biomarkers in these 4 days. ROC curves was for the complication predictive value.
Results : 1) 502 with and 448 without complication, pancreatic fistula （380，40%）had the highest morbidity, while the level A B C fistula were 278，90 and 12. 2) In the non-complication subgroup, the mean baseline，POD1, POD3 and POD 5 of PCT were 0.1, 0.81, 0.93, 0.57ug/L（P=0.118）; CRP were 8.39, 70.81，99.59, 49.49mg/L (P=0.000). In the complication subgroup, the mean baseline，POD1, POD3 and POD 5 of PCT were 0.09, 0.93, 0.77, 0.37(P=0.000), CRP were 9.30, 79.70, 153.01, 85.83. (P=0.000) 3) There were significant differences in the subgroups classified by occurrence of infectious complication, abdominal infection and sepsis in POD3 and POD 5 of PCT, and significant difference by occurrence of complication, pancreatic fistula in POD3 and POD 5 of CRP, WBC and neutrophil%. 5) The AUC of POD3 and POD 5 of PCT were 0.8, 0.7, 0.6 (P=0.000) to predict sepsis, abdominal infection and infectious complication. AUC of POD3 and POD5 of CRP and WBC were 0.7,0.6 (P=0.000)to predict complication and pancreatic fistula.
Conclusions : PCT is better to predict infectious complication, abdominal infection and sepsis while CRP, WBC and Neutrophil % are better to predict complication and pancreatic fistula.
Methods : 950 cases were recruited from 6 centers in China. Procalcitonin,C-reactive protein and WBC were measured on 1st, 3rd and 5th postoperative day . Chi-square test was for the complication risk factors. One-way ANOVA was for the comparison between the biomarkers in these 4 days. ROC curves was for the complication predictive value.
Results : 1) 502 with and 448 without complication, pancreatic fistula （380，40%）had the highest morbidity, while the level A B C fistula were 278，90 and 12. 2) In the non-complication subgroup, the mean baseline，POD1, POD3 and POD 5 of PCT were 0.1, 0.81, 0.93, 0.57ug/L（P=0.118）; CRP were 8.39, 70.81，99.59, 49.49mg/L (P=0.000). In the complication subgroup, the mean baseline，POD1, POD3 and POD 5 of PCT were 0.09, 0.93, 0.77, 0.37(P=0.000), CRP were 9.30, 79.70, 153.01, 85.83. (P=0.000) 3) There were significant differences in the subgroups classified by occurrence of infectious complication, abdominal infection and sepsis in POD3 and POD 5 of PCT, and significant difference by occurrence of complication, pancreatic fistula in POD3 and POD 5 of CRP, WBC and neutrophil%. 5) The AUC of POD3 and POD 5 of PCT were 0.8, 0.7, 0.6 (P=0.000) to predict sepsis, abdominal infection and infectious complication. AUC of POD3 and POD5 of CRP and WBC were 0.7,0.6 (P=0.000)to predict complication and pancreatic fistula.
Conclusions : PCT is better to predict infectious complication, abdominal infection and sepsis while CRP, WBC and Neutrophil % are better to predict complication and pancreatic fistula.
SESSION
Poster
Poster / Exhibition Hall and Lobby(2F) 1/1/1970 9:00 AM - 9:00 AM