Introduction : Acute pancreatitis is a disease that may lead complications and also cause morbidity and mortality. Chrysin has potential positive effects on pancreas because of the antioxidant and anti-inflammatory properties, but there is no study about pancreatic effects. In this study the effects of orally taken chrysin will be investigated in the treatment of acute pancreatitis

Methods : Twenty four Male Wistar albino rats were procured from Sel?k University Experimental Medical Research and Practice Centre. AP model was established by subcutaneous injections of cerulein (25 mg/kg) once a day.Chyrsin was performed to groups intraperitoneally. The effects of chyrsin were displayed by detecting pancreatic tissue of the experimental rats histopathologically according to the Schmidt scoring system.

Results : The outcome of groups such as biochemical results, histopathological outcomes which performed chyrsin provides significantly improvement in acute pancretitis model. Besides that the dose of the molecule lead further healing

Conclusions : According to present research, chyrsin application improved increased oxidative stress in experimental acut pancreatitis model, therewithal it was cured for both histopathological and oxidative stress outcomes. The present study shows that chyrsin can securely utilized in pancreatic diseases due to its antioxidant and pancreatoprotective specialities.