Introduction : Intracholecystic papillary-tubular neoplasm (ICPN) has recently been introduced as a new concept in the classification of gallbladder tumors. ICPN is defined as a mass-forming preinvasive neoplasm (>1cm) of the gall bladder and shows many similarities to intraductal papillary neoplasm of the bile duct (IPNB) and intraductal papillary mucinous neoplasm (IPMN). We analyzed the cases of ICPN and compared them with gall bladder cancer (non-ICPN) in our center.

Methods : We retrospectively reviewed the medical records of patients who were diagnosed with ICPN and/or Gall bladder cancer in our center from January 2010 to October 2017. Patient data and clinical outcomes were collected and analyzed.

Results : There were 11 patients who were diagnosed wtih ICPN and 144 patients who were diagnosed with gall bladder cancer (non-ICPN) in our center. There was no significant difference in demographics between the two groups. Two year survival rate was 83.3% in ICPN group and 73.2% in non-ICPN group (p=0.11). Among the 11 patients in ICPN group, three patients were diagnosed with ICPN with high grade dysplasia, and 8 patients were diagnosed with ICPN with adenocarcinoma (Invasive ICPN). Two patients died due to disease progression in ICPN group. Of the two patients, one patient who was diagnosed with ICPN with high grade dysplasia and multiple BilIN died due to peritoneal seeding.

Conclusions : : ICPN group show better survival rate than non-ICPN group without statistical significance. Concomitant ICPN and multiple bilIN may suggest a bad prognosis. Continued follow up of the patients and further research on ICPN should be needed