Detailed Abstract
[Liver Poster Presentation 5 - Transplantation]
[P040] The effects of intrapatient variability in tacrolimus on clinical outcomes in patients with liver transplantation during early stage
Eun Ji KIM1, Bo Ram KIM1, Jung Won CHO1, Jung Hwa LEE1, Eun Sook LEE2, Yun Mi YU2, Ho-Seoung HAN3,4, Yoo Seok YOON3,4, Jai Young CHOI3,4, Euni LEE2, YoungRok CHOI3,4
1Pharmacy, Seoul National University Bundang Hospital, Korea
2College of Pharmacy, Seoul National University, Korea
3Surgery, Seoul National University, College of Medicine, Korea
4Surgery, Seoul National University Bundang Hospital, Korea, Korea
Introduction : Tacrolimus has a narrow therapeutic range requiring concentration monitoring. The purpose of this study is to evaluate the effect of tacrolimus intrapatient variability (IPV, %) on clinical outcomes in liver transplantation.
Methods : A retrospective analysis using electronic medical records of liver transplant recipients from 2009 to 2016 was conducted in Seoul National University Bundang Hospital. IPV was calculated by using individual tacrolimus concentration and averaged tacrolimus concentration. Patients were divided into two groups based on the median IPV; high variability (HV) and low variability (LV) groups. The rate of deviation from the therapeutic range, the incidence of acute rejection, and post-transplant diabetes, the number of infection and estimated glomerular filtration rate (eGFR) within 6 months after transplantation were compared between two groups.
Results : Of 82 study subjects, HV group (17.3%) has more frequently deviated from the therapeutic range than the LV group (4.5%) (p
Conclusions : We compared the clinical outcomes between HV and LV groups within 6 months after liver transplantation. High IPV of tacrolimus concentration was strongly associated with increased frequency of deviation from the therapeutic range and the number of infection.
Methods : A retrospective analysis using electronic medical records of liver transplant recipients from 2009 to 2016 was conducted in Seoul National University Bundang Hospital. IPV was calculated by using individual tacrolimus concentration and averaged tacrolimus concentration. Patients were divided into two groups based on the median IPV; high variability (HV) and low variability (LV) groups. The rate of deviation from the therapeutic range, the incidence of acute rejection, and post-transplant diabetes, the number of infection and estimated glomerular filtration rate (eGFR) within 6 months after transplantation were compared between two groups.
Results : Of 82 study subjects, HV group (17.3%) has more frequently deviated from the therapeutic range than the LV group (4.5%) (p
Conclusions : We compared the clinical outcomes between HV and LV groups within 6 months after liver transplantation. High IPV of tacrolimus concentration was strongly associated with increased frequency of deviation from the therapeutic range and the number of infection.
SESSION
Liver Poster Presentation 5
Poster / Exhibition Hall and Lobby(2F) 3/30/2018 2:40 PM - 3:20 PM