Detailed Abstract
[Poster - Liver Disease/Surgery]
[P019] Impact of preoperative weight status on long-term prognosis in patients undergoing liver resection of hepatocellular carcinoma (a multicenter large cohort study)
Jiong-Jie YU1,2, Ju-Dong LI1,2, Xin-Fei XU1,2, Li-Yang SUN1,2, Jia-He WANG1,2, Wen-Tao YAN1,2, Bing QUAN1,2, Jian-Hong ZHONG3, Yi-Sheng HUANG4, Ya-Hao ZHOU5, Ting-Hao CHEN6, Hong WANG7, Wei-Min GU8, Feng SHEN1, Tian YANG1
1Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital of Second Military Medical University, China
2Department of Clinical Medicine, Second Military Medical University, China
3Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, China
4Department of Oncology, Affiliated Zhongshan Hospital of Guangdong Medical University, China
5Department of Hepatobiliary Surgery, Pu’er People’s Hospital, China
6Department of General Surgery, Ziyang First People’s Hospital, China
7Department of General Surgery, Liuyang People’s Hospital, China
8The First Department of General Surgery, He Fourth Hospital of Harbin, China epa, China
Introduction : Overweight has been identified as a significant risk associated with long-term prognosis after liver resection of hepatocellular carcinoma (HCC). Although underweight is not unusual in HCC patients, its association with long-term outcomes after resection of HCC remains unclear. Therefore, we investigated the relationship between different preoperative weight status and long-term outcomes in patients undergoing HCC resection.
Methods : Patients treated with curative liver resection of HCC at six Chinese institutions between 2001 and 2013 were divided into 3 groups: underweight group (BMI < 18.5), normal-weight group (BMI 18.5 ~ 25.0) and overweight group (BMI > 25.0). Baseline characteristics and clinical variables were collected and compared. Univariate and multivariate Cox-regression analyses were performed to identify risk factors of overall survival (OS) and recurrence-free survival (RFS).
Results : Of all 1,524 patients, there were 891 normal-weight, 107 underweight, and 526 overweight. Underweight and overweight patients had significantly poorer OS and RFS than normal-weight patients (all P < 0.01). Multivariate Cox-regression analysis identified that underweight and overweight were significantly associated with decreased OS (HR 1.217, 95% CI 1.19-1.56, P = 0.02, and HR 1.59, 95% CI 1.36-1.81, P < 0.01), and RFS (HR 1.30, 95% CI: 1.19-1.53, P < 0.01, and HR 1.34, 95% CI 1.17-1.54, P < 0.01).
Conclusions : Apart from overweight, underweight was also significantly associated with decreased OS and RFS in patients undergoing liver resection for HCC.
Methods : Patients treated with curative liver resection of HCC at six Chinese institutions between 2001 and 2013 were divided into 3 groups: underweight group (BMI < 18.5), normal-weight group (BMI 18.5 ~ 25.0) and overweight group (BMI > 25.0). Baseline characteristics and clinical variables were collected and compared. Univariate and multivariate Cox-regression analyses were performed to identify risk factors of overall survival (OS) and recurrence-free survival (RFS).
Results : Of all 1,524 patients, there were 891 normal-weight, 107 underweight, and 526 overweight. Underweight and overweight patients had significantly poorer OS and RFS than normal-weight patients (all P < 0.01). Multivariate Cox-regression analysis identified that underweight and overweight were significantly associated with decreased OS (HR 1.217, 95% CI 1.19-1.56, P = 0.02, and HR 1.59, 95% CI 1.36-1.81, P < 0.01), and RFS (HR 1.30, 95% CI: 1.19-1.53, P < 0.01, and HR 1.34, 95% CI 1.17-1.54, P < 0.01).
Conclusions : Apart from overweight, underweight was also significantly associated with decreased OS and RFS in patients undergoing liver resection for HCC.
SESSION
Poster
Poster / Exhibition Hall and Lobby(2F) 1/1/1970 9:00 AM - 9:00 AM