Detailed Abstract
[Poster - Liver Disease/Surgery]
[P017] Association of family history with cancer recurrence and survival in patients with hepatitis b-related hepatocellular carcinoma (a propensity score matching analysis)
Ju-Dong LI1,2, Xin-Fei XU1,2, Jiong-Jie YU1,2, Zhen-Li LI1, Hao XING1, Han WU1, Han ZHANG1, Chao LI1, Ming-Da WANG1, Meng-Chao WU1, Wan-Yee LAU1,3, Tian YANG1
1Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital of Second Military Medical University, China
2Department of Clinical Medicine, Second Military Medical University, China
3Faculty of Medicine, The Chinese University of Hong Kong, China, China
Introduction : A family history of liver cancer is regarded as a risk factor for hepatocellular carcinoma (HCC) development. We investigated the association between family history and cancer recurrence and survival in patients with hepatitis B virus (HBV)-related HCC.
Methods : Patients who underwent curative resection of HBV-related HCC between 2003 and 2013 from a tertiary hepatobiliary center in China were enrolled in this study. A family history was defined as a self-reported history of primary liver cancer in the first-degree relatives. Propensity score matching (PSM) and multivariable Cox-regression analyses were performed to compare the overall survival (OS) and recurrence-free survival (RFS) between patients with and without a family history of liver cancer.
Results : Of 1,112 patients, 183 patients (16.5%) had a family history of liver cancer. A family history was not associated with OS and RFS (P = 0.994 and 0.428) in the entire cohort. Using PSM, 179 pairs of patients with and without a family history but with comparable baseline characteristics and operative variables were created. A family history was associated with decreased OS and RFS (P = 0.042 and 0.006) in the PSM cohort. On multivariable Cox-regression analyses, a family history was significantly associated with decreased OS (HR: 1.574, 95% CI: 1.171-2.116, P = 0.003) and RFS (HR: 1.534, 95% CI: 1.176-2.002, P = 0.002) after adjusting for other prognostic factors.
Conclusions : A family history of liver cancer was associated with decreased OS and RFS rates after curative resection in patients with HBV-related HCC.
Methods : Patients who underwent curative resection of HBV-related HCC between 2003 and 2013 from a tertiary hepatobiliary center in China were enrolled in this study. A family history was defined as a self-reported history of primary liver cancer in the first-degree relatives. Propensity score matching (PSM) and multivariable Cox-regression analyses were performed to compare the overall survival (OS) and recurrence-free survival (RFS) between patients with and without a family history of liver cancer.
Results : Of 1,112 patients, 183 patients (16.5%) had a family history of liver cancer. A family history was not associated with OS and RFS (P = 0.994 and 0.428) in the entire cohort. Using PSM, 179 pairs of patients with and without a family history but with comparable baseline characteristics and operative variables were created. A family history was associated with decreased OS and RFS (P = 0.042 and 0.006) in the PSM cohort. On multivariable Cox-regression analyses, a family history was significantly associated with decreased OS (HR: 1.574, 95% CI: 1.171-2.116, P = 0.003) and RFS (HR: 1.534, 95% CI: 1.176-2.002, P = 0.002) after adjusting for other prognostic factors.
Conclusions : A family history of liver cancer was associated with decreased OS and RFS rates after curative resection in patients with HBV-related HCC.
SESSION
Poster
Poster / Exhibition Hall and Lobby(2F) 1/1/1970 9:00 AM - 9:00 AM