Introduction : Solid pseudopapillary tumors of the pancreas are considered benign conditions but up to 15% can present with aggressive behavior. Due to the rarity of this disease, there is still much debate regarding the ideal management. We present a video of a surgery performed on a 28/M diagnosed with solid pseudopapillary tumor of the pancreas after neoadjuvant chemotherapy.

Methods : A 28/M diagnosed with solid pseudopapillary tumor of the pancreas underwent 10 cycles of neoadjuvant chemotherapy. The patient underwent open pylorus preserving pancreaticoduodenectomy with concurrent portal vein resection and end-to-end anastomosis.

Results : The patient had an uneventful post-operative course and was discharged without complications.

Conclusions : Neoadjuvant chemotherapy combined with en-bloc tumor resection is a viable treatment option for patients diagnosed with aggressive solid pseudopapillary tumor of the pancreas.